VTE prophylaxis following hip and knee surgery
RAG rating
Document type
Hertfordshire and West Essex ICB
Output type
Pharmacy / Prescribing

Apixaban (generic 1st line)

Generic apixaban is first line direct acting oral anticoagulant (DOAC) of choice for the indications listed below:

  • Treatment for non-valvular atrial fibrillation (AF)
    • (Guidelines for oral anticoagulation of patients with non-valvular atrial fibrillation (AF) to prevent stroke in adults – click here)
  • Treatment of deep vein thrombosis (DVT) or pulmonary embolism (PE) and prevention of recurrent DVT and PE
  • Primary prevention of venous thromboembolic events in patients who have had hip or knee replacement surgery

All DOAC options (apixaban, edoxaban, rivaroxaban and dabigatran) are available in line with the recommendations from respective published NICE TA’s for above indications.

Version number
Developed by
Pharmacy and Medicines Optimisation Team, Hertfordshire and West Essex (HWE) ICB with relevant HWE ICS stakeholders.
Approved by
Hertfordshire & West Essex Area Prescribing Committee
Date approved / updated
November 2023
Review date
This HWE APC recommendation is based upon the evidence available at the time of publication. This recommendation will be reviewed upon request in the light of new evidence becoming available.
Superseded version